Technical Program

Paper Detail

Paper: PS-1B.2
Session: Poster Session 1B
Location: H Fläche 1.OG
Session Time: Saturday, September 14, 16:30 - 19:30
Presentation Time:Saturday, September 14, 16:30 - 19:30
Presentation: Poster
Publication: 2019 Conference on Cognitive Computational Neuroscience, 13-16 September 2019, Berlin, Germany
Paper Title: Episodic memory retrieval is supported by rapid replay of episode content
Authors: G. Elliott Wimmer, Yunzhe Liu, Neža Vehar, University College London, United Kingdom; Tim Behrens, University of Oxford, United Kingdom; Raymond J Dolan, University College London, United Kingdom
Abstract: Episodic memory retrieval entails the reactivation of neural representations that reflect elements of an experience. The characteristics of retrieval and whether and how it is supported by time-compressed reactivation or ‘replay’ of the sequential episode components remain unknown. We studied participants who had been exposed to unique episodes followed by a memory test the next day using magnetoencephalography (MEG). When the goal was to retrieve subsequent elements of an episode, accuracy for weaker memories was supported by reverse sequential replay with a compression factor greater than 60. However, when the goal was to retrieve elements preceding a cue, retrieval was supported instead by forward replay. Replay effects were the strongest in participants with lower mean performance. In participants with strong memories, we found evidence for repeated brief clustered reactivation of episode elements. Our results demonstrate novel mechanisms underlying episodic memory retrieval that inform how the brain constructs world models and how memory may be used in decision making.